Gene editing
Snrpntm1Rsnk
Alias:
Snrpntm1Kaj
PWS-ICHs
Snrpntm1(SNRPN)Rsnk
Basic Information
The Pradar-Willi syndrome imprinting center (PWS-IC), including exon 1, was replaced with the human exon 1 and the shortest region of deletion overlap (PWS-SRO). Transcripts resulted from the human promoter, as expected. (J:105412)
Basic Information
MGI ID
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Because of their genetic and physiological similarities with humans, mouse models are essential for understanding human illnesses. Advances in molecular biology and gene editing improve disease replication in mice, allowing researchers to get a better understanding of disease causes, identify biomarkers, and create treatments.
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#) :related diseases count
Phenotypes：
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References
Disease models are key instruments in biomedical research, and their literature reports are critical to the advancement of research. These publications provide researchers with a comprehensive theoretical foundation by detailing the design procedures, application regions, and outcomes analysis of disease models.
Title
PMID
Journal
Year
IF
Comparison
BioGPT