Exons 3-8 were flanked by loxP sites upon removal of a FRT-flanked neo cassette. Deletion of the floxed sequence would remove the four in-frame ATGs, causing a premature frame shift and termination of translation. (J:105283)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count