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The transgene comprises a full-length, 1865 base pair mouse cDNA encoding the short (38.7 kDa), normally brain-specific enzyme isoform under control of the human ubiquitin C promoter. The coding sequence is followed by the SV40 splice and polyadenylation signals, and the entire construct is flanked by loxP sequences. Protein levels detected by western blot analysis are similar in heart, kidney and lung of transgenic mice homozygous for a targeted mutation of the gene and of wild-type mice, but higher in brain and much lower in liver of the former. (J:105483)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
