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A targeting construct was designed to replace the T-cell receptor gamma variable 1 gene as well as the joining region and exons 1 and 2 of the T-cell receptor gamma constant 4 gene with a neomycin resistance cassette. Removal of this region would prevent any rearrangement and the possibility of pairing other variable gamma genes with an otherwise intact constant 4 gene. Absence of Tcrg-V1 mRNA in RT-PCR of mutant spleen and thymus confirmed successful ablation. (J:105477)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
