The betaGeo cassette that is flanked with Frt sites in Aco1tm1Mwh was removed by mating with mice expressing Flp recombinase (Tg(ACTFLPe)9205Dym), generating an exon 3 floxed allele with normal gene expression. (J:103414, J:104538)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count