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The locus was replaced with an H19Xba cassette consisting of murine H19 sequence from 4 kb upstream of the transriptional start site to 7.5 kb downstream of the gene which has been modified with the inserion of 2 XbaI linkers into a SacI site at +580 bp in exon 1. The knockin mutation conserves all sequences at the endogenous locus, with the placement of a single loxP site upstream of the gene and a neo-loxP cassette downstream of the gene. Northern blot analysis indicates expression of H19 RNA is reduced to 57% of wild-type in heterozygotes with a maternally inherited mutant allele. (J:37089, J:104484)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
