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A neomycin resistance cassette replaced about 2.5 kb of sequence including the entire second and third exons which encode the N-terminal portion of the CUB domain. This deletion creates a frameshift such that a truncated transcript containing nothing downstream of the signal peptide in the original frame, and only 21 amino acids downstream of the frameshift translated into the new frame. RT-PCR failed to detect wild-type transcript in mutants. Protein was not detected in mutant MEFs. (J:104148)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
