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A beta-gal reporter gene was fused in frame with the endogenous ATG and a loxP-flanked neo cassette. The first and second coding exons of the locus, encoding the BH3 region, were removed. Crossing with mice expressing cre in the germline removed the floxed neo cassette. mRNA was absent in mutant liver, lung, heart, and kidney. (J:104487)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
