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Exon 1, encoding the first transmembrane domain through the beginning of the first P1 loop was disrupted by homologous recombination. An IRES-lacZ-SV40pA-neo cassette containing a stop codon in all three reading frames replaced the first 21 amino acids. In situ hybridization and real time PCR showed that the targeted allele is not expressed in either mutant brain or heart samples. (J:103747)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
