A targeting vector was designed to flank the direct repeat sequence downstream of the differentially methylated domain (DMD). A neomycin resistance cassette flanked by a FRT sites that was included downstream of the floxed sequence was removed via FLPe expression. (J:117666)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count