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Cre recombinase was used to invert a 75-kb loxP-flanked region of the locus. The region encompasses all of the J-alpha gene segments, the C-alpha gene segment and enhancer E-alpha. In this allele the J-alpha gene segments lie in the opposite transcriptional orientation compared to the V-alpha gene segments. Accordingly, initial V-alpha to J-alpha rearrangements on the allele occur by inversion, resulting in retention of the Tcrd genes that lie within the locus in the mature alpha-beta T cells. (J:101719)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
