ES cells containing a previously targeted Abcb1a allele (Abcb1atm1Bor) were targeted again with a vector replacing exons 3 and 4 of Abcb1b with a neomycin selection cassette. The vector contained a MluI linker 3' of the neo cassette that allowed detection of the Abcb1b disruption linked to the previous Abcb1a disruption by long-range restriction mapping. (J:39804)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
2
74

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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