A targeting vector was designed to insert a loxP site upstream of exon 1, followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette. (J:102870)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count