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A targeting vector was designed such that the locus contains the Swedish/London-FAD mutation and a "humanized" Abeta domain sequence in exons 16-18 under the control of the endogenouse APP promoter. A pA sequence and neomycin resistance gene was included in the vector. (J:102542)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
