ES cells with a hygromycin resistance gene replacing the entire Apoa5 locus were targeted a second time with a vector designed to replace exon 4 of Apoc3 with a neomycin resistance gene. Northern blot revealed that the mutant mice lacked both Apoa5 and Apoc3 transcripts. (J:102319)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
Insertion, Intragenic deletion
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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