A targeting vector was designed to replace J1 through J4 with a neomycin resistance cassette followed by the 36-65VDJ region with the following amino acid substitutions: A9V, Y32N, I51N, T58I, K59T, S77N, V100E, Y107K, with numbering from the mature amino terminus of the H chain. (J:102308)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count