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The transgene comprises the entire human gene, including the promoter and at least 30 kb of flanking genomic DNA, from the BAC clone 23C20. The number of integrated copies, based on Southern blot analysis, is between between 5 and 10 per diploid genome. Northern blot analysis revealed high levels of transgene-derived mRNA in liver, skin, and spleen and lower levels in lung, heart and testis. (J:79757)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
