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A targeting construct was designed to replace arginine with methionine at position 131 (R131M) in exon 4, disrupting the phopshate groove but retaining catalytic activity and integrity of the hydrophobic groove. Protein was expressed normally in mutant ES cells. (J:102388)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
