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A pgk-neo flanked by FRT sites with a loxP site at the 3' end was inserted into intron 4. A second loxP site was inserted into intron 3. Crossing with mice expressing FLP recombinase removed the pgk-neo, leaving mice with a flanked exon 4. Exon 4 encodes the integrin I-like domain. Cre-mediated deletion of this exon would result in a translational frameshift that generates a premature stop codon. (J:102190)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
