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The targeting event deleted a part of exon 1 containing the translation initiation codon, replacing it with a DNA segment containing a lacZ gene and a Pgk-neo cassette. The bacterial beta-galactosidase is not expressed in vivo. RT-PCR analysis of homozygous mutant mice amplified no transcript, and immunoblot analysis detected only cross-reacting proteins and not the major, specific band. (J:102528)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
