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EN
The targeting event results in the disruption of exon 1 by insertion of a LacZ gene (in-frame with the initiation codon) and neomycin selection cassette without deletion of any of the endogenous gene sequence. T cells in this strain retain high levels of P2X7 activity. The 13a isoform is expressed in these mice but no expression of the 13b or 13c isoforms is detected. (J:97422, J:101945, J:149750, J:194518)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
