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A single loxP site was inserted upstream of exon 18 and a floxed hygromycin resistance cassette was inserted downstream of exon 19. The hygromycin resistance cassette was selectively excised from correctly targeted ES cells by transient transfection with a cre-expression vector. Exons 18 and 19, encoding part of the ATPase-helicase motifs, were thus flanked by loxP sites in the resulting ES cells. (J:42997, J:101729)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
