Cre mediated recombination by mating to Tg(CMV-cre)1Ipc mice was used to remove exon 2. Deletion of exon 2 introduces a frame shift followed by a premature termination codon, thus producing a null allele. (J:101819)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count