A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts are detectable in salivary gland, subcortical region of the brain, cerebellum, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, lung, liver, pancreas, kidney, spleen, thymus, bone marrow, skin, gallbladder, urinary bladder, stomach, large intestine, cecum, epididymis, seminal vesicle, coagulating gland, prostate gland, ovaries and uterus. Striking lacZ (beta-galactosidase) expression is detectable in brain, spinal cord and ganglia. Other tissues displaying X-Gal staining are kidney, urinary bladder, salivary glands, and male reproductive system.

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Disruption caused by insertion of vector
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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