A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues analyzed, beta-galactosidase expression from this allele is detectable in brain, spinal cord, sciatic nerve, eye, Harderian glands, thymus, lymph nodes, aorta, heart, lung, kidney, urinary bladder, trachea, larynx, esophagus, pituitary gland, adrenal glands, salivary glands, tongue, skeletal muscle, skin, male and female reproductive systems.
Basic Information
Disruption caused by insertion of vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count