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An 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II alpha promoter was used to drive the human microtubule-associated protein tau with the R406W mutation postnataly in forebrain neurons. Protein was expressed the greatest in the hippocampus, followed in decreasing amounts by the neocortex, the olfactory bulb, the striatum, and the thalamus. Mutant protein was barely detectable in the midbrain, the cerebellum and the spinal cord. Lines 502, 492 and 483 demonstrated similar expression patterns. (J:100958)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
