A floxed neo was inserted into intron 1 and a third loxP site was inserted in the 3' UTR. RT-PCR and Northern blot confirmed aberrant splicing of exon 1 to the neo cassette, creating a nonfunctional allele. (J:101098)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count