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The targeting vector was designed to replace the coding sequences from exon 2, including the translation initiation codon, the N-terminal half LIM motif, part of the LIM1 domain, and 0.5 kb of intron 2 with a lacZ reporter gene and a loxP flanked neomycin resistance cassette. Transcription of the lacZ insertion was evident in various stages of embryonic development. Absence of endogenous transcript and protein in mutants was confirmed by Northern and Western blots, respectively. (J:100289)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
