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The transgene expresses the mutant human amyloid protein precursor APPSwe, which bears the Swedish (K670N/M671L) mutation, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. (J:69967)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
