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LoxP sites were inserted to flank exons 18-20, which encode part of the first RNase III domain. Deletion of this sequence putatively leads to out-of-frame splicing of all downstream exons, including the second RNase III and the dsRNA-binding domains, and results in complete ablation of enzymactic activity. An frt-flanked neo was inserted into intron 17 and was removed by crossing mice with a strain that expresses Flp recombinase in the germ line. (J:100546)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
