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LoxP sites were inserted to flank exons 11 and 12. Cre-mediated deletion of these exons would result in the out-of-frame splicing of exon 10 to exon 13 and the generation of a prematurely terminated 468-amino acid protein. This mutant protein would be shorter than most truncated Apc proteins. (J:100461)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
