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A truncated form of Fgfr1 lacking the intracellular tyrosine kinase domain was ligated downstream of the rabbit beta-globin intron and placed under the control of the rat Gnrh1 promoter/enhancer region. The human growth hormone polyA sequence was inserted at the 3' end of the Fgfr1 cDNA. A transcript of approximately 1.5 kb was present only in the forebrain, where Gnhr1 neurons reside, corresponding to the size of the mutant Fgfr1. Expression was not found in the hindbrain or liver. (J:95057)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
