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A targeting construct was designed to insert a lacZ-puro cassette into exon 1, deleting sequence that encodes transcriptional regulatory regions and for the CUT domain required for DNA binding. In-frame stop codons were included in the vector, following the lacZ sequence to prevent the production of a truncated Onecut2 protein or read-through transcripts initiated in the lacZ or puro cassettes. RT-PCR failed to detect Onecut2 transcript in mutant liver samples. (J:100352)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
