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The 3' UTR of Gapdh, bearing two missense mutations in the trimer interface region, was substituted in place of the endogenous 3' UTR via homologous recombination. The loxP flanked neomycin resistance cassette was excised out after selection by transient transfection of the surviving ES cells with pCMB-cre. (J:99724)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
