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A construct was generated having a 3.6 kb fragment of the mouse Upk2 promoter, cre recombinase and a polyA signal. The transgene was purified and microinjected into fertilized FVB/N oocytes. Three founder lines 4,5,6) were obtained, all showing germline transmission and urothelium-specific cre mRNA expression (not detected in any other tissues). Mice established from founder 6 were crossed to reporter mice to verify cre recombinase activity in the urothelium. (J:99613)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
