Ntrk1^tm1Ddg

A phenylalanine to alanine substitution mutation at residue 592 (F592A) was introduced via homologous recombination using a mutagenized construct with an FRT flanked neomycin resistance tag. Heterozygotes were bred with mice bearing Tg(ACTFLPe)9205Dym which expressed FLP1 recombinase. The resulting allele has the F592A mutation but the neomycin resistance cassete has been excised. (J:99603)