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The mouse metallothionein-1 promoter drives expression of the human p190 BCR/ABL fusion gene that has the ABL oncogene fused head to tail with the 5' exons of the BCR gene with the break occurring in the first intron. This fusion gene produces the p190 protein with abnormal tyrosin kinase activity. Founder 623 was used to generate the transgenic line. (J:91174)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
