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A targeting construct was designed to insert a rearranged H chain of a physiologically selected ssDNA-binding antibody into the locus. The DQ52 and JH elements were deleted upon recombination. Flow cytometry demonstrated that 67% of heterozygous mice expressed only the mutant allele, and up to 31% expressed the endogenous allele exclusively. (J:71617)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
