The gene trap vector inserted into an intron of the locus and resulted in alternative splicing to a cryptic 3' splice site located in the neo, creating a hypomorphic allele. The expected transcript would be 503 nt long, however, RT-PCR demonstrated that the major PCR product was only 93 nt long and did not hybridize to a U3 probe. (J:98861, J:151685)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Gene trapped
Insertion of gene trap vector
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Comparison
Al agent
Tutorials
Back to top