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A targeting vector was constructed to flank exon 8 with loxP sites. A neomycin selection cassette was placed downstream of exon 8, within the floxed sequence. Gene expression was demonstrated to be highly variable, ranging from 10-95% of normal, with the average reduction being 65%. Immunohistochemical analysis demonstrated that protein levels were variably reduced. (J:98560)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
