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This transgene consists of the CMV enhancer with the chicken beta-actin promoter, a floxed Blasticidin resistance gene and the Angpt16 gene. Cre mediated recombination removes the Blasticidin resistance gene and allows expression of Angpt16 in brown adipose tissue, heart, and skeletal muscle. Angpt16 concentration increased approximately twofold. Three lines were made. This is a representative record representing lines 8-1, 9-1, and 16-1, all of which have identical phenotypes. (J:97552)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
