Exon 12, which encodes part of the extracellular domain and is common to all isoforms, was disrupted by the insertion of a neomycin resistance gene. Flow cytometry of splenocytes, lymphocytes, lymph node and bone marrow cells with an antibody recognizing all isoforms failed to detect protein on any cells. (J:57681)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion
--
1
2
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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