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A targeting vector containing a PGK-neo was inserted into exon 1, 30 bp downstream from the ATG. Northern and Western blot analyses confirmed disruption of transcript and protein, respectively, from exon 1. A transcript was found that appeared to result from the fusion of exon 2 to 403 bp from the 3' end of the intron instead of to the neo transcript. A truncated protein was also found at significantly reduced levels than wild-type. (J:98334)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
