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This transgene contains Cre recombinase and human placental alkaline phosphatase under the control of Gdf5 promoter and enhancer elements. A BAC containing the Gdf5 locus was modified by the insertion of a cre-IRES-ALPP into the translational start site to create the transgene. Gdf5 drives expression in developing joints. This line represents three that were created. (J:97780)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
