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Tcra-Jtm2.1Krg ES cells (where the Trja49 promoter (Rr319) and gene segment were replaced with a loxP site flanked neomycin resistance gene cassette and the neo cassette was removed through subsequent cre-mediated recombination) were targeted with a vector replacing the TEA (T early alpha) promoter with a floxed neo cassette. The region between the loxP site in place of Trja49 and the upstream loxP site in place of the TEA promoter was deleted through subsequent cre-mediated recombination. This deletes segments Traj50-61 and the non-coding TEA exon. No gross deficiency was found in alphabeta TCR expression or alphabeta T cell development in mutant mice. (J:97736)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
