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Exons 5-7, which encode amino acids 155-251 and make up the middle of the N-terminal kinase domain, were replaced with a neo. If readthrough occurred, splicing from exons 4-8 would result in a frameshift mutation. Immunoblotting of mutant MEFs confirmed the lack of protein. (J:97140)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
