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A single loxP site was inserted into intron 4 and a loxP-flanked neomycin-thymidine kinase selection cassette into intron 5 of the gene. The loxP sites flank a region of the gene encoding most of the first kringle domain necessary for the biological activity of the corresponding protein. Transient Cre recombinase transfection removed the selection cassette prior to the production of chimeric mice. (J:97145)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
