Txnrd1^tm1Marc

LoxP sites flanking exon 15, which encodes 22 amino acids and the C-terminally located redox center consisting of Gly-Cys-Sec-Gly, and 1.7 kb of the 3' UTR containing the selenocysteine insertion element, essential for cotranslational Sec incorporation at the UGA codon, AU-rich mRNA instability elements and the endogenous transcription stop signal and a neo cassette flanked by frt sites were inserted via homologous recombination. (J:96818)