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The gene trap cassette inserted into the intron between exon 2 and exon 3 of the gene. RT-PCR and quantitative PCR (qPCR) analyses revealed absence of mRNA expression in both the cortex and hippocampus of homozygous mutant mice. In situ hybridization confirmed that mRNA signals are almost undetectable in mutant brain. (J:250032)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
