Log In|Sign Up
EN
A 250 bp fragment of the mouse metallothionein promoter spanning nucleotides -185 to +65 was cloned upstream of a 4.6 kb fragment of the PML/RARA type L cDNA. The PML/RARA fusion gene included the RARA 3' untranslated region and the two presumed polyadenylation signals. 6 copies of the transgene were incorporated into the genome at a single site. ZnSo4 in the drinking water caused strong transgene induction in the liver after only 2 days of treatment (both at the mRNA and protein levels). Expression levels decreased with continuous treatment, with all expression lost by 30 days of treatment. (J:87302)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
